Tutorial III: The strategy to integrate metabolic flux, cell metabolism with metabolomics to study the mechanism of drug action

Shanghai New International Expo Center (SNIEC) Conference Room M11(1st floor) in Hall E1
  • The strategy to integrate metabolic flux, cell metabolism with metabolomics to study the mechanism of drug action

  • Song Yue

    Agilent Technologies

    Song, Yue received Ph. D. in Pharmacognosy from China Pharmaceutical University in 2005 and is currently serving as LCMS application engineer in Agilent Technologies Co. , Ltd. Shanghai Branch.

    The strategy to integrate metabolic flux, cell metabolism with metabolomics to study the mechanism of drug action

    Metabolomics has been widely used in the mechanism research of drug action, it measures the molecular composition of a cell and identify the changed metabolites between control and treated group, then the pathway mapping clues the specific pathways which are activated due to biological response to drug treatments. Based on these metabolomics results, how to further reveal in vivo pathway activity, how to confirm and validate from cell biology level, these are very important for more clear clarification the mechanism of drug action. Metabolic flux analysis uses isotope labeling to track the flow of metabolites through a pathway, Seahorse XF is like a video camera that measures the rate of change in the two major energy metabolism pathways of cell simultaneously in live cells and in real-time. This presentation will introduce an integrated strategy by combing metabolic Flux, cell metabolism with metabolomics to provide both biological relevance and detailed molecular information to the study of the mechanism of drug action.

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