Recombinant Human Fibroblast Growth Factor-basic (rh-bFGF)

Product Name: Recombinant Human Fibroblast Growth Factor-basic (rh-bFGF)

Catalog Number: NRPA07S

Packing Details: 5 µg, 10 µg, 100 µg, 1 mg

Formulation: Lyophilized from 5 mM PB, pH 7.4

Mol. Wt.: 17.2 kDa

Resources: Escherichia coli (E. coli)

Purity: ≥95% by SDS-PAGE analysis

Endotoxin: <1.0 EU/µg protein

Storage Condition: -20oC

Storage Duration: 3 years

Biological Activity: The EC50, calculated by the dose-dependant proliferation of mouse BALB/c 3T3 cells is 0.25~1 ng/ml, corresponding to a specific activity of 1*106~4*106 units/mg protein.

Description:

Fibroblast Growth Factor-basic (bFGF), also known as FGF-2, is a heparin-binding member of the FGF superfamily of molecules. It plays important roles in cell proliferation and differentiation associated with embryogenesis, tissue regeneration, wound healing, CNS development, angiogenesis, and tumor progression. Additionally, bFGF is a potent mitogenic agent for a wide variety of mesoderm-derived cells including BALB/c 3T3 fibroblasts, capillary and endocardial endothelial cells, myoblasts, vascular smooth muscle cells, mesothelial cells, glial and astroglial cells, and adrenal cortex cells.

Recombinant human bFGF in E. coli is a single, non-glycosylated, polypeptide chain containing 155 amino acids and having a molecular mass of 17.2 kDa